Rabbit Anti-Human MMP-1 Polyclonal Antibody | MyBioSource MBS300589 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human MMP-1 Polyclonal Antibody

catalog :

MBS300589

quantity :

7 ml

price :

265 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300589

products type :

Antibody

products full name :

Rabbit Anti-Human MMP-1 Polyclonal Antibody

products short name :

MMP-1

other names :

interstitial collagenase isoform 2; Interstitial collagenase; interstitial collagenase; fibroblast collagenase; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloprotease 1; matrix metalloproteinase 1; matrix metallopeptidase 1; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1

products gene name :

MMP-1

other gene names :

MMP1; MMP1; CLG; CLGN; CLG; MMP-1

uniprot entry name :

MMP1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Rabbit

sequence length :

403

form :

7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:200. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Placenta, Bladder, Breast, Ovarian Carcinoma

other info2 :

Immunogen: Synthetic peptide from near C-terminus of human MMP-1 protein. Control Tissue: Bladder, Breast, Ovarian Carcinoma, Placenta. Cellular Localization: Cytoplasm. Entrez Gene Code: 4312. Pathway: Proteases and Protease Regulators

products description :

Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMP or disturbances in the differential control of MMP by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1), 72kDa gelatinase A / type IV collagenase (MMP-2), and 92kDa gelatinase B / type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis.

ncbi gi num :

225543094

ncbi acc num :

NP_001139410.1

ncbi gb acc num :

NM_001145938.1

ncbi mol weight :

52 kDa (Unglyco-sylated) and 57 kDa (Glycosylated)

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway 576264!!Basigin Interactions Pathway 106065!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Collagen Degradation Pathway 730309!!Degradation Of The Extracellular Matrix Pathway 576263!!Endothelins Pathway 137958!!Extracellular Matrix Organization Pathway 576262!!Glucocorticoid Receptor Regulatory Network Pathway 138014

ncbi summary :

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

size :

7 ml

price :

265 USD