Rabbit Anti-Human PDGFR-alpha? Polyclonal Antibody | MyBioSource MBS300462 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human PDGFR-alpha? Polyclonal Antibody

catalog :

MBS300462

quantity :

1 ml

price :

410 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse, human, rat, dog

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS300462

products type :

Antibody

products full name :

Rabbit Anti-Human PDGFR-alpha? Polyclonal Antibody

products short name :

PDGFR alpha

other names :

platelet-derived growth factor receptor alpha; Platelet-derived growth factor receptor alpha; platelet-derived growth factor receptor alpha; CD140 antigen-like family member A; CD140a antigen; PDGF-R-alpha; PDGFRA/BCR fusion; alpha-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 2; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; platelet-derived growth factor receptor, alpha polypeptide; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 2; PDGFR-2; CD_antigen: CD140a

products gene name :

PDGFR alpha

other gene names :

PDGFRA; PDGFRA; CD140A; PDGFR2; PDGFR-2; RHEPDGFRA; PDGFR2; RHEPDGFRA; PDGF-R-alpha; PDGFR-alpha; PDGFR-2

uniprot entry name :

PGFRA_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Chicken, Dog, Frog, Mouse, Pig, Rat

sequence length :

1089

form :

1.0 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:100. IHC Positive Control: Skin, Ovarian Carcinoma

other info2 :

Immunogen: Synthetic peptide derived from C-terminus of human PDGFR alpha. Control Tissue: Kidney, Ovarian Carcinoma, Skin. Cellular Localization: Cytoplasm, Membrane. Entrez Gene Code: 5156. Pathway: Signal Transduction

products description :

PDGFR (Platelet Derived Growth Factor Receptor) exhibits two different isoforms, alpha and beta coded by two different genes. PDGF-alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF-beta receptors are expressed on neurons. This antibody is specific for PDGFR alpha and does not react with PDGFR beta.

ncbi gi num :

5453870

ncbi acc num :

NP_006197.1

ncbi gb acc num :

NM_006206.4

ncbi mol weight :

190 kDa

ncbi pathways :

ATF-2 Transcription Factor Network Pathway 138006!!Adaptive Immune System Pathway 366160!!Angiogenesis Pathway 198772!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Cardiac Progenitor Differentiation Pathway 712094!!Central Carbon Metabolism In Cancer Pathway 1059538!!Central Carbon Metabolism In Cancer Pathway 1084231!!Choline Metabolism In Cancer Pathway 1059539!!Choline Metabolism In Cancer Pathway 1084232

ncbi summary :

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

size :

1 ml

price :

410 USD

more info or order :

MyBioSource product webpage