Rabbit Anti-Human Granzyme B Polyclonal Antibody | MyBioSource MBS300443 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human Granzyme B Polyclonal Antibody

catalog :

MBS300443

quantity :

7 ml

price :

265 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300443

products type :

Antibody

products full name :

Rabbit Anti-Human Granzyme B Polyclonal Antibody

products short name :

Granzyme B

other names :

granzyme B; Granzyme B; granzyme B; C11; CTLA-1; T-cell serine protease 1-3E; cathepsin G-like 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic serine protease B; fragmentin 2; fragmentin-2; human lymphocyte protein; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E

other gene names :

GZMB; GZMB; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP

uniprot entry name :

GRAB_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Dog, Mouse, Pig, Rat

sequence length :

247

form :

7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format for this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Tonsil

other info2 :

Immunogen: Synthetic peptide from N-terminus of human granzyme B. Control Tissue: Tonsil. Cellular Localization: Cytoplasm. Entrez Gene Code: 3002. Pathway: Apoptosis

products description :

Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and are stored within cytolytic granules and released by effector cells during degradation. This antibody should be useful for the localization of granzyme B-containing lytic granules and for the characterization of activated CTLs or NK cells.

ncbi gi num :

221625528

ncbi acc num :

NP_004122.2

ncbi gb acc num :

NM_004131.4

ncbi mol weight :

32 kDa

ncbi pathways :

Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway 105657!!Allograft Rejection Pathway 920963!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Apoptosis Pathway 198797!!Apoptosis Pathway 105648!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Caspase Cascade In Apoptosis Pathway 137974!!Downstream Signaling In Naive CD8+ T Cells Pathway 138018

ncbi summary :

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

size :

7 ml

price :

265 USD