product summary
request information :
company name :
MyBioSource
product type :
antibody
product name :
Mouse Anti-Human Thyroglobulin Monoclonal Antibody (Clone SPM517)
catalog :
MBS300374
quantity :
1 ml
price :
465 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
immunohistochemistry - paraffin section, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS300374
products type :
Antibody
products full name :
Mouse Anti-Human Thyroglobulin Monoclonal Antibody (Clone SPM517)
products short name :
Thyroglobulin
other names :
thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin; N/A
other gene names :
TG; TG; TGN; AITD3; Tg
uniprot entry name :
THYG_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
SPM517
host :
Mouse
reactivity :
Human
sequence length :
2768
form :
1.0 ml mouse monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
storage stability :
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
tested application :
Immunohistochemistry (IHC) Paraffin
app notes :
Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:200. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen RetrievalNone Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: 1:200. IHC Positive Control: Thyroid
other info2 :
Immunogen: Human thyroglobulin. Control Tissue: Thyroid. Cellular Localization: Cytoplasm. Entrez Gene Code: 7038. Pathway: Cancer Markers
products description :
Thyroglobulin is a dimeric protein produced by thyroid epithelial cells (thyrocytes) and tumor cells derived from thyrocytes. Thyroglobulin is secreted and stored in the follicular lumen and then used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is expressed in thyroid carcinomas of the papillary and follicular types.
ncbi gi num :
55770862
ncbi acc num :
NP_003226.4
ncbi gb acc num :
NM_003235.4
ncbi mol weight :
330 kDa
ncbi pathways :
Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Thyroxine (Thyroid Hormone) Production Pathway 920992
ncbi summary :
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
size :
1 ml
price :
465 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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