Rabbit Anti-Human Annexin VI Polyclonal Antibody | MyBioSource MBS300164 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human Annexin VI Polyclonal Antibody

catalog :

MBS300164

quantity :

7 ml

price :

280 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, dog

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300164

products type :

Antibody

products full name :

Rabbit Anti-Human Annexin VI Polyclonal Antibody

products short name :

Annexin VI

other names :

annexin A6 isoform 1; Annexin A6; annexin A6; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calphobindin II; calphobindin-II; chromobindin-20; lipocortin VI; p70; annexin A6; 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70

other gene names :

ANXA6; ANXA6; ANX6; CBP68; ANX6; CPB-II

uniprot entry name :

ANXA6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human. Predicted Reactivity: Bovine, Dog, Mouse, Pig

sequence length :

673

form :

7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide. (For IHC only)

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin, Western Blotting (WB)

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at RT. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Liver. Western Blot . Recommended Starting Protocol: Dilute the antibody 1:25. Incubate for 1 hour at room temperature. The dilution is an estimate; actual results may differ because of variability in methods and protocols. Optimal dilution and procedure should be determined by the end user. Western Blot Positive Control: 293T Cell Lysate

other info2 :

Immunogen: Synthetic peptide corresponding to N-terminus of human Annexin VI. Control Tissue: Liver, Tonsil. Cellular Localization: Membrane. Entrez Gene Code: 309. Pathway: Signal Transduction

products description :

The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. When overexpressed in A431 cells, Annexin VI causes a partial reversal of the transformed phenotype.

ncbi gi num :

71773329

ncbi acc num :

NP_001146.2

ncbi gb acc num :

NM_001155.4

ncbi mol weight :

75 kDa

ncbi pathways :

Calcium Regulation In The Cardiac Cell Pathway 198906!!Prostaglandin Synthesis And Regulation Pathway 198912

ncbi summary :

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

size :

7 ml

price :

280 USD