catalog number :
MBS2889438
products full name :
Proliferation marker protein Ki-67
products short name :
[Proliferation marker protein Ki-67]
products name syn :
[Antigen identified by monoclonal antibody Ki-67; Antigen KI-67]
other names :
[proliferation marker protein Ki-67 isoform 2; Proliferation marker protein Ki-67; proliferation marker protein Ki-67; marker of proliferation Ki-67; Antigen identified by monoclonal antibody Ki-67]
products gene name :
[MKI67]
other gene names :
[MKI67; MKI67; KIA; MIB-; MIB-1; PPP1R105; Antigen KI-67Curated; Antigen Ki67Curated]
sequence positions :
[1122-1234aa]
sequence :
EKTTKIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEF
LALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLD
LAGTLPGSKRQLQTPKEKAQALEDLAGFKELFQTP
storage stability :
Store at -20°C for 6 months. (Avoid repeated freezing and thawing).
tested application :
ELISA (EIA), Western Blot (WB), Affinity Purification (AP)
image1 heading :
SDS-PAGE
other info1 :
Organism Species: Homo sapiens(human). Buffer: 50mM NaH 2 PO 4 , 500mM NaCl Buffer with 500mM Imidazole,10% glycerol(PH8).0).
products description :
Recombinant protein with His-tag
ncbi acc num :
NP_001139438.1
ncbi gb acc num :
NM_001145966.1
ncbi mol weight :
12.43 kD
ncbi summary :
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
uniprot summary :
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).