product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Rat Von Hippel-Lindau disease tumor suppressor ELISA Kit
catalog :
MBS288882
quantity :
48-Strip-Wells
price :
355 USD
more info or order :
image
image 1 :
product information
catalog number :
MBS288882
products type :
ELISA Kit
products full name :
Rat Von Hippel-Lindau disease tumor suppressor ELISA Kit
products short name :
[Von Hippel-Lindau disease tumor suppressor]
products name syn :
[Von Hippel-Lindau disease tumor suppressor; pVHL; Vhl]
other names :
[von Hippel-Lindau disease tumor suppressor; Von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; pVHL]
products gene name :
[Vhl]
other gene names :
[Vhl; Vhl; Vhlh]
uniprot entry name :
VHL_RAT
reactivity :
Rat
sequence length :
185
specificity :
Recombinant and natural Rat Von Hippel-Lindau disease tumor suppressor
storage stability :
For long term storage, please store the entire kit at -20 degree C.
image1 heading :
Typical Testing Data/Standard Curve (for reference only)
other info1 :
Samples: Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Detection Range: 0.156-10 ng/mL. Sensitivity: <0.087 ng/mL
other info2 :
Intra-assay Precision: Intra-Assay CV: <=4.7%. Inter-assay Precision: Inter-Assay CV: <=7.2%
products description :
Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
ncbi gi num :
16258813
ncbi acc num :
NP_434688.1
ncbi gb acc num :
NM_052801.1
uniprot acc num :
Q64259
ncbi mol weight :
21,215 Da
ncbi pathways :
ECV Complex Pathway (434764); ECV Complex Pathway (890606); HIF-1 Signaling Pathway (695233); Pathways In Cancer (83493); Renal Cell Carcinoma Pathway (83495); Renal Cell Carcinoma Pathway (519); Ubiquitin Mediated Proteolysis Pathway (83448); Ubiquitin Mediated Proteolysis Pathway (466)
ncbi summary :
may act as a tumor suppressor [RGD, Feb 2006]
uniprot summary :
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 ().
size1 :
48-Strip-Wells
price1 :
355 USD
size2 :
96-Strip-Wells
price2 :
475
size3 :
5x96-Strip-Wells
price3 :
2030
size4 :
10x96-Strip-Wells
price4 :
3700
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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