Mouse Gelsolin ELISA Kit | MyBioSource MBS2886136 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Gelsolin ELISA Kit

catalog :

MBS2886136

quantity :

48-Strip-Wells

price :

355 USD

product information

catalog number :

MBS2886136

products type :

ELISA Kit

products full name :

Mouse Gelsolin ELISA Kit

products short name :

[Gelsolin]

products name syn :

[Gelsolin; Actin-depolymerizing factor; ADF; Brevin; Gsn; Gsb]

other names :

[gelsolin isoform 1; Gelsolin; gelsolin; gelsolin; Actin-depolymerizing factor; ADF; Brevin]

products gene name :

[Gsn]

other gene names :

[Gsn; Gsn; ADF; Gsb; ADF]

uniprot entry name :

GELS_MOUSE

reactivity :

Mouse

sequence length :

780

storage stability :

For long term storage, please store the entire kit at -20 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

products description :

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

28916693

ncbi acc num :

NP_666232.2

ncbi gb acc num :

NM_146120.4

uniprot acc num :

P13020

ncbi mol weight :

80,763 Da

ncbi pathways :

Apoptosis Pathway (1323524); Apoptotic Cleavage Of Cellular Proteins Pathway (1323549); Apoptotic Execution Phase Pathway (1323548); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (1323550); Fc Gamma R-mediated Phagocytosis Pathway (114297); Fc Gamma R-mediated Phagocytosis Pathway (106590); Programmed Cell Death Pathway (1323523); Regulation Of Actin Cytoskeleton Pathway (198389); Regulation Of Actin Cytoskeleton Pathway (83286); Regulation Of Actin Cytoskeleton Pathway (500)

uniprot summary :

Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation. Protein type: Secreted, signal peptide; Actin-binding; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Secreted. Cellular Component: actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; extracellular region; extracellular space; focal adhesion; lamellipodium; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; protein complex; ruffle; sarcoplasm. Molecular Function: actin binding; calcium ion binding; metal ion binding; myosin II binding; protein binding; protein domain specific binding. Biological Process: actin filament capping; actin filament polymerization; actin filament severing; actin nucleation; actin polymerization and/or depolymerization; apoptosis; barbed-end actin filament capping; cell projection organization and biogenesis; negative regulation of virion penetration into host cell; phagocytosis, engulfment; phosphoinositide-mediated signaling; positive regulation of actin nucleation; protein destabilization; regulation of cell adhesion; sequestering of actin monomers; striated muscle atrophy; vesicle-mediated transport

size1 :

48-Strip-Wells

price1 :

355 USD

size2 :

96-Strip-Wells

price2 :

475

size3 :

5x96-Strip-Wells

price3 :

2030

size4 :

10x96-Strip-Wells

price4 :

3700