Human Solute carrier family 40 member 1 ELISA Kit | MyBioSource MBS2884453 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Solute carrier family 40 member 1 ELISA Kit

catalog :

MBS2884453

quantity :

48-Strip-Wells

price :

380 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS2884453

products type :

ELISA Kit

products full name :

Human Solute carrier family 40 member 1 ELISA Kit

products short name :

Solute carrier family 40 member 1

products name syn :

Solute carrier family 40 member 1; Ferroportin-1; Iron-regulated transporter 1; SLC40A1; FPN1; IREG1; SLC11A3; MSTP079

other names :

solute carrier family 40 member 1; Solute carrier family 40 member 1; solute carrier family 40 member 1; solute carrier family 40 (iron-regulated transporter), member 1; Ferroportin-1; Iron-regulated transporter 1

products gene name :

SLC40A1

other gene names :

SLC40A1; SLC40A1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3; FPN1; IREG1; SLC11A3

uniprot entry name :

S40A1_HUMAN

reactivity :

Human

sequence length :

571

specificity :

This assay recognizes recombinant and natural human Solute carrier family 40 member 1. No significant cross-reactivity or interference was observed.

storage stability :

For long term storage, please store the entire kit at -20 degree C.

other info1 :

Samples: Serum, Plasma, Urine, tissue homogenates and Cell culture supernates and Other biological fluids. Detection Range: 0.15 ng/mL -10.0 ng/mL. Sensitivity: 0.05 ng/mL.

products description :

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of human Solute carrier family 40 member 1 concentrations in serum, Plasma, Urine, tissue homogenates and Cell culture supernates and Other biological fluids. Principle of the Assay The microtiter plate provided in this kit has been pre-coated with an antibody specific to Solute carrier family 40 member 1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation specific for Solute carrier family 40 member 1 and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain Solute carrier family 40 member 1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of Solute carrier family 40 member 1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

7657100

ncbi acc num :

NP_055400.1

ncbi gb acc num :

NM_014585.5

uniprot acc num :

Q9NP59

ncbi mol weight :

62,542 Da

ncbi pathways :

Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (1269948); Metal Ion SLC Transporters Pathway (1269930); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); SLC-mediated Transmembrane Transport Pathway (1269907); Transmembrane Transport Of Small Molecules Pathway (1269903); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (1269923)

ncbi summary :

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

uniprot summary :

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2q32. Cellular Component: basolateral plasma membrane; cytoplasm; integral to membrane; integral to plasma membrane; intracellular; multivesicular body; plasma membrane; synaptic vesicle. Molecular Function: ferrous iron transmembrane transporter activity; iron ion transmembrane transporter activity; peptide hormone binding; protein binding; receptor activity. Biological Process: cellular iron ion homeostasis; lymphocyte homeostasis; negative regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport. Disease: Hemochromatosis, Type 4

size1 :

48-Strip-Wells

price1 :

380 USD

size2 :

96-Strip-Wells

price2 :

500

more info or order :

MyBioSource product webpage