catalog number :
MBS2882584
products type :
ELISA Kit
products full name :
Human Protein S100-A1 ELISA Kit
products short name :
[Protein S100-A1]
products name syn :
[Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1; S100A1; S100A]
other names :
[protein S100-A1; Protein S100-A1; protein S100-A1; S100 calcium binding protein A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1]
products gene name :
[S100A1]
other gene names :
[S100A1; S100A1; S100; S100A; S100-alpha; S100A]
uniprot entry name :
S10A1_HUMAN
storage stability :
For long term storage, please store the entire kit at -20 degree C.
image1 heading :
Typical Testing Data/Standard Curve (for reference only)
other info1 :
Assay Type: Sandwich. Detection Range: 0.156-10 ng/mL. Sensitivity: 0.085ng/ml
other info2 :
Intra-Assay CV: <=8.1%. Inter-Assay CV: <=10.2%. Recovery: 103%
ncbi acc num :
NP_006262.1
ncbi gb acc num :
NM_006271.1
ncbi mol weight :
10,546 Da
ncbi summary :
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
uniprot summary :
S100A1: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Belongs to the S-100 family. Protein type: Calcium-binding; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: M band; neuron projection; nucleus; protein complex; sarcoplasmic reticulum; Z disc. Molecular Function: ATPase binding; calcium ion binding; calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity. Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction; substantia nigra development
size4 :
10x96-Strip-Wells