Mouse Fibroblast growth factor 23 ELISA Kit | MyBioSource MBS2881372 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Fibroblast growth factor 23 ELISA Kit

catalog :

MBS2881372

quantity :

48-Strip-Wells

price :

305 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2881372

products type :

ELISA Kit

products full name :

Mouse Fibroblast growth factor 23 ELISA Kit

products short name :

[Fibroblast growth factor 23]

products name syn :

[Fibroblast growth factor 23; FGF-23; Fgf23]

other names :

[fibroblast growth factor 23; Fibroblast growth factor 23; fibroblast growth factor 23; fibroblast growth factor 23]

products gene name :

[Fgf23]

other gene names :

[Fgf23; Fgf23; FGF-23]

uniprot entry name :

FGF23_MOUSE

reactivity :

Mouse

sequence length :

251

specificity :

ecombinant and natural Mouse X-box-binding protein 1,XBP-1

storage stability :

For long term storage, please store the entire kit at -20 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Tissue Homogenates, Cell Culture Supernates Or Other Biological Fluids. Detection Range: 0.78-50 ng/mL. Sensitivity: <0.3 ng/mL

other info2 :

Intra-assay Precision: Intra-Assay CV: <=4.7%. Inter-assay Precision: Inter-Assay CV: <=9.9%

products description :

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

12083589

ncbi acc num :

NP_073148.1

ncbi gb acc num :

NM_022657.4

uniprot acc num :

Q9EPC2

ncbi mol weight :

27,758 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1324638); Adaptive Immune System Pathway (1323640); Axon Guidance Pathway (1323598); Cytokine Signaling In Immune System Pathway (1323763); DAP12 Interactions Pathway (1323743); DAP12 Signaling Pathway (1323744); Developmental Biology Pathway (1323597); Downstream Signal Transduction Pathway (1324645); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (1323654); Downstream Signaling Of Activated FGFR1 Pathway (1324563)

ncbi summary :

This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]

uniprot summary :

FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family. Protein type: Secreted, signal peptide; Secreted; Cytokine. Cellular Component: extracellular region; extracellular space. Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding; type 1 fibroblast growth factor receptor binding. Biological Process: cell differentiation; cellular phosphate ion homeostasis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; phosphate ion homeostasis; positive regulation of transcription, DNA-dependent; regulation of bone mineralization; vitamin D catabolic process

size1 :

48-Strip-Wells

price1 :

305 USD

size2 :

96-Strip-Wells

price2 :

395

size3 :

5x96-Strip-Wells

price3 :

1615

size4 :

10x96-Strip-Wells

price4 :

2880

more info or order :

MyBioSource product webpage