Mouse Programmed cell death 1 ligand 1 ELISA Kit | MyBioSource MBS2880716 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Programmed cell death 1 ligand 1 ELISA Kit

catalog :

MBS2880716

quantity :

48-Strip-Wells

price :

355 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2880716

products type :

ELISA Kit

products full name :

Mouse Programmed cell death 1 ligand 1 ELISA Kit

products short name :

[Programmed cell death 1 ligand 1]

products name syn :

[Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; Cd274; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; CD274]

other names :

[programmed cell death 1 ligand 1; Programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; CD274 antigen; B7 homolog 1; B7-H1; CD_antigen: CD274]

products gene name :

[Cd274]

other gene names :

[Cd274; Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1]

uniprot entry name :

PD1L1_MOUSE

reactivity :

Mouse

sequence length :

290

storage stability :

For long term storage, please store the entire kit at -20 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, Plasma, Tissue Homogenates, Cell Culture Supernates Or Other Biological Fluids.

products description :

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

11230798

ncbi acc num :

NP_068693.1

ncbi gb acc num :

NM_021893.3

uniprot acc num :

Q9EP73

ncbi mol weight :

32,780 Da

ncbi pathways :

Adaptive Immune System Pathway (1323640); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (1323646); Immune System Pathway (1323639); PD-1 Signaling Pathway (1323651)

ncbi summary :

The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]

uniprot summary :

CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: cell surface; external side of plasma membrane; integral to membrane; membrane; plasma membrane. Molecular Function: protein binding. Biological Process: cell surface receptor linked signal transduction; immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of cell migration; positive regulation of T cell proliferation; response to cytokine stimulus; signal transduction; T cell costimulation

size1 :

48-Strip-Wells

price1 :

355 USD

size2 :

96-Strip-Wells

price2 :

475

size3 :

5x96-Strip-Wells

price3 :

2030

size4 :

10x96-Strip-Wells

price4 :

3700

more info or order :

MyBioSource product webpage