Rabbit anti-human Asialoglycoprotein receptor 1 (ASGR1) Polyclonal antibody | MyBioSource MBS286422 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Asialoglycoprotein receptor 1 (ASGR1) Polyclonal antibody

catalog :

MBS286422

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS286422

products type :

Antibody

products full name :

Rabbit anti-human Asialoglycoprotein receptor 1 (ASGR1) Polyclonal antibody

products short name :

[Asialoglycoprotein receptor 1 (ASGR1)]

products name syn :

[CLEC4H1; HL-1; ASGPR 1; Asialoglyco protein Receptor; C-type lectin domain family 4 member H1; Hepatic lectin H1]

other names :

[Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1]

products gene name :

[ASGR1]

other gene names :

[ASGR1; ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1; CLEC4H1; ASGP-R 1; ASGPR 1; HL-1]

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

sequence length :

291

specificity :

Reacts with: Mouse, Rat, Pig.

purity :

Rabbit Polyclonal IgG, affinity purified by Protein A.

form :

Liquid

concentration :

1 mg/mL

storage stability :

Storage: Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving. **Avoid repeated freeze-thaw cycles.**. Stability: Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8°C.

tested application :

SDS-PAGE; Western Blot (WB); ELISA (EIA)

app notes :

WB=1:500-2000. ELISA=1:500-1000 . IHC-P=1:400-800. IHC-F=1:400-800. ICC=1:100-500. IF=1:100-500. Not yet tested in other applications. Optimal working dilutions must be determined by the end user.

other info1 :

Immunogen: KLH conjugated synthetic peptide derived from Human ASGR1.

other info2 :

Buffer: 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin 300 and 50% Glycerol.

products description :

ASGR is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds and internalizes galactose-terminated glycoproteins (asialoglycoproteins or ASGP) from the circulation. The mouse ASGR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGR1 (MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGR1 ECD is 89% and 79% identical to the ASGR1 ECD of rat and human, respectively.

ncbi gi num :

18149183

ncbi acc num :

BAB83508.1

ncbi mol weight :

Predicted MW: 32 kDa

ncbi pathways :

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

ncbi summary :

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

uniprot summary :

ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: integral to plasma membrane. Molecular Function: protein binding. Biological Process: receptor-mediated endocytosis

size1 :

0.1 mg

price1 :

245 USD

size2 :

0.5 mg

price2 :

620

size3 :

1 mg

price3 :

850

more info or order :

MyBioSource product webpage