Rabbit anti-human Lactoferrin (LTF) Polyclonal antibody | MyBioSource MBS286411 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Lactoferrin (LTF) Polyclonal antibody

catalog :

MBS286411

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS286411

products type :

Antibody

products full name :

Rabbit anti-human Lactoferrin (LTF) Polyclonal antibody

products short name :

[Lactoferrin (LTF)]

products name syn :

[HLF2; LF; GIG12; Lactotransferrin; Growth-inhibiting protein 12; Talalactoferrin; Lfcin-H; Kaliocin-1]

other names :

[lactoferrin, partial; Lactotransferrin; lactotransferrin; lactotransferrin; Growth-inhibiting protein 12; Talalactoferrin]

products gene name :

[LTF]

other gene names :

[LTF; LTF; LF; HLF2; GIG12; HEL110; GIG12; LF; Lactoferrin; Lfcin-H]

clonality :

polyclonal

isotype :

IgG

host :

rabbit

reactivity :

Human

sequence length :

475

purity :

Rabbit Polyclonal IgG, affinity purified by Protein G.

form :

Liquid

concentration :

3 mg/mL

storage stability :

Storage: Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving. **Avoid repeated freeze-thaw cycles.**. Stability: Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8°C.

tested application :

IHC-F, IHC-P, ELISA. Not yet tested in other applications. Optimal working dilutions must be determined by the end user

app notes :

ELISA=1:500-1000. IHC-P=1:100-500. IHC-F=1:100-500

other info1 :

Source: Rabbit. Immunogen: Recombinant human LTF protein. Buffer: 0.01M PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol

products description :

LTF, a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Human colostrum has the highest concentration, followed by human milk, then cow milk. Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa).Lactoferrin antimicrobial activity is due partly to its high affinity for Fe (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.

ncbi gi num :

2104522

ncbi acc num :

AAB57795.1

ncbi mol weight :

Predicted MW: 28.2 kDa

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Mtb Iron Assimilation By Chelation Pathway (645273); Phagosomal Maturation (early Endosomal Stage) Pathway (645268); Response Of Mtb To Phagocytosis Pathway (645269)

ncbi summary :

This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

uniprot summary :

LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter. Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; nucleus; protein complex; secretory granule; specific granule. Molecular Function: heparin binding; iron ion binding; protein binding; protein serine/threonine kinase activator activity. Biological Process: activation of NF-kappaB transcription factor; antibacterial humoral response; antifungal humoral response; cell redox homeostasis; cellular protein metabolic process; humoral immune response; innate immune response in mucosa; iron assimilation by chelation and transport; negative regulation of apoptosis; negative regulation of ATPase activity; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of viral genome replication; negative regulation of viral reproduction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of toll-like receptor 4 signaling pathway; regulation of cytokine production; regulation of tumor necrosis factor production; retinal homeostasis

size1 :

0.1 mg

price1 :

245 USD

size2 :

0.5 mg

price2 :

620

size3 :

1 mg

price3 :

850

more info or order :

MyBioSource product webpage