Recombinant Human IGF1R Protein | MyBioSource MBS286111 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human IGF1R Protein

catalog :

MBS286111

quantity :

0.1 mg

price :

370 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS286111

products type :

Recombinant Protein

products full name :

Recombinant Human IGF1R Protein

products short name :

[IGF1R]

products name syn :

[IGF-I receptor; CD221; IGF-1R; IGF1R]

other names :

[insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; insulin like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor]

products gene name :

[IGF1R]

other gene names :

[IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor]

uniprot entry name :

IGF1R_HUMAN

host :

E.coli

sequence positions :

[AA 763-931]

sequence length :

1367

purity :

> 95% as determined by SDS-PAGE . Affinity purification.

form :

Lyophilized or Liquid . Lyophilized from 20mM PB, 300mM NaCI, pH 7.7.

concentration :

1 mg/mL

storage stability :

The thermal stability is described by the loss rate. The loss rate was determined by the accelerated thermal degradation test, that is incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% withing the expiration adate under appropiate storage condition. Store it under sterile conditions at -80°C .It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze/thaw cycles. Sampleas are stable for up to twelve months from date of receipt at -80°C.

tested application :

Western Blot (WB), ELISA (EIA, SDS-PAGE- Antigen.

image1 heading :

SDS PAGE

other info1 :

Source: Prokaryotic expression. Protein Residues: N-terminal His-tag

other info2 :

Usage: Reconstitute in PBS or others.

products description :

The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growthpromoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.

ncbi gi num :

4557665

ncbi acc num :

NP_000866.1

ncbi gb acc num :

NM_000875.4

uniprot acc num :

P08069

ncbi mol weight :

31 kDa

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Apoptosis Pathway (198797); Breast Cancer Pathway (1435207); Breast Cancer Pathway (1435182); EGFR Tyrosine Kinase Inhibitor Resistance Pathway (1404798); EGFR Tyrosine Kinase Inhibitor Resistance Pathway (1402107); Endochondral Ossification Pathway (198812)

ncbi summary :

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

uniprot summary :

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: integral to plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane; receptor complex. Molecular Function: identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity. Biological Process: immune response; inactivation of MAPKK activity; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; protein amino acid autophosphorylation; protein tetramerization; regulation of JNK cascade; signal transduction. Disease: Insulin-like Growth Factor I, Resistance To

size1 :

0.1 mg

price1 :

370 USD

size2 :

0.5 mg

price2 :

1045

size3 :

1 mg

price3 :

1455

more info or order :

MyBioSource product webpage