catalog number :
MBS2801108
products full name :
Rabbit Anti-Human Ghrelin Receptor Polyclonal Antibody
products short name :
[Ghrelin Receptor]
products name syn :
[GH-releasing peptide, receptor; Qowfi Hormone Secretagogue Receptor, GHRP.]
reactivity :
Human, Rat, Mouse.
purity :
Rabbit Polyclonal lgG, the antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
form :
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
storage stability :
Shipped at 2-8°C. Store it under sterile conditions at -20°C to -80°C upon receiving. Avoid repeated freezing and thawing cycles. Store at -20"C for one year. Avoid repeated freezelthaw cycles. The lyophilized antibody is stable at room temperature for at.least one month and for greater than a year when kept at -20"C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8"C.
tested application :
Western Blot (WB), Immunohistochemistry (IHC). Not yet tested in other applications.
Optimal working dilutions must be determined by end user.
app notes :
WB: 1:1000-2000. IHC: 1:100-200
other info1 :
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human GHSR (092847).
products description :
Ghrelin receptor is a G protein-coupled receptor which binds ghrelin and plays a role in energy homeostasis and regulation of body weight. Ghrelin is an appetite-regulating factor secreted from peripheral organs which is involved in regulation of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activated by binding of Ghrelin to the Ghrelin receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. One of thg'{ihportant features of GHSRIa displays constitutive activity possessing basal:sotivity in the absence of an agonist, resulting in a high degree of receptor iqternalization as well as of signaling activity.
ncbi mol weight :
Predicted MW: 41 kDa