E2F1 antibody [N1N3] | MyBioSource MBS270497 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

E2F1 antibody [N1N3]

catalog :

MBS270497

quantity :

0.1 ml

price :

360 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat, cow

application :

western blot, immunoprecipitation

product information

catalog number :

MBS270497

products type :

Antibody

products full name :

E2F1 antibody [N1N3]

products short name :

E2F1

products name syn :

E2F transcription factor 1; E2F-1 antibody; RBAP1 antibody; RBBP3 antibody; RBP3 antibody; E2F1 antibody; retinoblastoma-binding protein 3 antibody; RBAP-1 antibody; PRB-binding protein E2F-1 antibody; RBBP-3 antibody; transcription factor E2F1 antibody; PBR3 antibody; retinoblastoma-associated protein 1 antibody; E2F transcription factor 1 antibody

other names :

transcription factor E2F1; Transcription factor E2F1; transcription factor E2F1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBBP-3; retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; E2F transcription factor 1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1

products gene name :

E2F1

other gene names :

E2F1; E2F1; RBP3; E2F-1; RBAP1; RBBP3; RBBP3; E2F-1; RBAP-1; RBBP-3

uniprot entry name :

E2F1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse. Predicted Reactivity: Chicken (86%), Rat (97%), Bovine (96%)

sequence length :

437

purity :

Purified by antigen-affinity chromatography.

form :

Liquid

concentration :

1 mg/ml

storage stability :

Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.

tested application :

Immunoprecipitation (IP), Western Blot (WB)

app notes :

Immunoprecipitation: 1:100-1:500. Western blot: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher.

other info1 :

Cellular Localization: Nucleus. Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Predicted Target Size: 47 kDa. Positive Controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, NIH-3T3

other info2 :

Immunogen: Recombinant fragment corresponding to a region within amino acids 43 and 217 of E2F1 (Uniprot ID#Q01094). Antigen Species: Human. Research Area: Cancer; Type of cancer; Ovarian; Cancer; Type of cancer; Prostate cancer; Signal Transduction; Signaling through enzyme-linked cell surface receptors; PI 3-Kinase

products description :

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq]. Product Description: Rabbit Polyclonal antibody to E2F1 (E2F transcription factor 1)

ncbi gi num :

12669911

ncbi acc num :

NP_005216

ncbi gb acc num :

NM_005225

uniprot acc num :

Q01094

ncbi mol weight :

46,920 Da

ncbi pathways :

Activation Of BH3-only Proteins Pathway 105658!!Activation Of NOXA And Translocation To Mitochondria Pathway 105660!!Activation Of PUMA And Translocation To Mitochondria Pathway 105661!!Adipogenesis Pathway 198832!!Apoptosis Pathway 105648!!Assembly Of The Pre-replicative Complex Pathway 105821!!Association Of Licensing Factors With The Pre-replicative Complex Pathway 105900!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!CDC6 Association With The ORC:origin Complex Pathway 105823

ncbi summary :

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

size :

0.1 ml

price :

360 USD