Rat Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit | MyBioSource MBS2703005 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

catalog :

MBS2703005

quantity :

24-Strip-Wells

price :

225 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2703005

products type :

ELISA Kit

products full name :

Rat Cartilage Oligomeric Matrix Protein (COMP) ELISA Kit

products short name :

[Cartilage Oligomeric Matrix Protein (COMP)]

products name syn :

[MED; EDM1; EPD1; PSACH; THBS5; TSP-5; Pseudoachondroplasia,Epiphyseal Dysplasia 1,Multiple; Thrombospondin 5]

other names :

[cartilage oligomeric matrix protein; Cartilage oligomeric matrix protein; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein; Thrombospondin-5; TSP5]

products gene name :

[COMP]

other gene names :

[COMP; COMP; MED; EDM1; EPD1; TSP5; PSACH; THBS5; COMP; TSP5]

reactivity :

Rat

sequence length :

704

specificity :

This assay has high sensitivity and excellent specificity for detection of COMP. No significant cross-reactivity or interference between COMP and analogues was observed.

storage stability :

The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. Detection Range: 0.312-20ng/mL. Sensitivity: <0.127ng/mL

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level COMP were tested 20 times on one plate, respectively. Intra-Assay: CV<10%. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level COMP were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100. Inter-Assay: CV<12%

products description :

Intended Uses: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of COMP in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

ncbi gi num :

40217843

ncbi acc num :

NP_000086.2

ncbi gb acc num :

NM_000095.2

uniprot acc num :

P49747

ncbi mol weight :

77,214 Da

ncbi pathways :

ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Integrin Cell Surface Interactions Pathway (106110); Malaria Pathway (152665); Malaria Pathway (152657)

ncbi summary :

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]

uniprot summary :

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 ().

size1 :

24-Strip-Wells

price1 :

225 USD

size2 :

48-Strip-Wells

price2 :

370

size3 :

96-Strip-Wells

price3 :

490

size4 :

5x96-Strip-Wells

price4 :

2030

size5 :

10x96-Strip-Wells

price5 :

3780

more info or order :

MyBioSource product webpage