Human Toll Like Receptor 5 (TLR-5) ELISA Kit | MyBioSource MBS269871 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Toll Like Receptor 5 (TLR-5) ELISA Kit

catalog :

MBS269871

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS269871

products type :

ELISA Kit

products full name :

Human Toll Like Receptor 5 (TLR-5) ELISA Kit

products short name :

Toll Like Receptor 5 (TLR-5)

other names :

Toll-like receptor 5; Toll-like receptor 5; toll-like receptor 5; toll/interleukin-1 receptor-like protein 3; systemic lupus erythematosus susceptibility 1; toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3

products gene name :

TLR-5

other gene names :

TLR5; TLR5; SLE1; TIL3; SLEB1; MELIOS; TIL3

uniprot entry name :

TLR5_HUMAN

reactivity :

Human

sequence length :

858

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant TLR-5 concentration. Assay Type: Sandwich. Detection Range: 20 ng/ml-0.312 ng/ml

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Human TLR-5 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

215274239

ncbi acc num :

O60602.4

ncbi mol weight :

97,834 Da

ncbi pathways :

Immune System Pathway (106386); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Innate Immune System Pathway (106387); Legionellosis Pathway (469200); Legionellosis Pathway (469186); MyD88 Cascade Initiated On Plasma Membrane Pathway (205107); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459); Pathogenic Escherichia Coli Infection Pathway (516)

ncbi summary :

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

uniprot summary :

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q41-q42. Cellular Component: plasma membrane; integral to membrane. Molecular Function: interleukin-1 receptor binding; transmembrane receptor activity. Biological Process: positive regulation of interleukin-8 production; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; male gonad development; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; inflammatory response; positive regulation of toll-like receptor signaling pathway; toll-like receptor 10 signaling pathway. Disease: Legionnaire Disease, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1; Melioidosis, Susceptibility To

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage