ELISA/assay

Rat Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) ELISA Kit

MBS269585

48-Strip-Wells

290 USD

ELISA Kit

Rat Chemokine C-X3-C-Motif Receptor 1 (CX3CR1) ELISA Kit

Chemokine C-X3-C-Motif Receptor 1 (CX3CR1)

Chemokine (C-X3-C motif) receptor 1; CX3C chemokine receptor 1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28

CX3CR1

CX3CR1; CX3CR1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CMKBRL1; GPR13; C-X3-C CKR-1; CX3CR1; CMK-BRL1

CX3C1_HUMAN

Rat

355

Store all reagents at 2-8 degree C.

Samples: Rat serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant CX3CR1 concentration. Detection Range: 10 ng/ml-0.156 ng/ml. Sensitivity: 0.05ng/ml.

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

20380137

AAH28078.1

43,969 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358)

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; GPCR, family 1; Motility/polarity/chemotaxis; Receptor, cytokine; Receptor, GPCR; Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: neuron projection; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; chemotaxis; cell adhesion; macrophage chemotaxis; negative regulation of cell migration; microglial cell activation during immune response. Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To

48-Strip-Wells

290 USD

96-Strip-Wells

450