ELISA/assay

Human Toll Like Receptor 1 (TLR-1) ELISA Kit

MBS269475

48-Strip-Wells

275 USD

ELISA Kit

Human Toll Like Receptor 1 (TLR-1) ELISA Kit

Toll Like Receptor 1 (TLR-1)

Toll-like receptor 1; Toll-like receptor 1; toll-like receptor 1; toll/interleukin-1 receptor-like protein; toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD_antigen: CD281

TLR-1

TLR1; TLR1; TIL; CD281; rsc786; TIL. LPRS5; KIAA0012; TIL

TLR1_HUMAN

Human

786

Store all reagents at 2-8 degree C.

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant TLR-1 concentration. Assay Type: Sandwich. Detection Range: 10 ng/ml-0.156 ng/ml

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Human TLR-1 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

146291086

Q15399.3

90,291 Da

Activated TLR4 Signalling Pathway (106400); Beta Defensins Pathway (530759); Defensins Pathway (530757); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); Regulation Of Toll-like Receptor Signaling Pathway (920955); Toll Like Receptor 2 (TLR2) Cascade Pathway (106402); Toll Like Receptor 4 (TLR4) Cascade Pathway (106398); Toll Like Receptor TLR1:TLR2 Cascade Pathway (106403)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

TLR1: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 4p14. Cellular Component: phagocytic vesicle membrane; membrane; integral to plasma membrane; plasma membrane. Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity. Biological Process: MyD88-dependent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; macrophage activation; positive regulation of interleukin-6 biosynthetic process; innate immune response; immune response; detection of triacylated bacterial lipoprotein; signal transduction; inflammatory response; toll-like receptor 1 signaling pathway. Disease: Leprosy, Susceptibility To, 5

48-Strip-Wells

275 USD

96-Strip-Wells

420