ELISA/assay

Rat Secondary Lymphoid Tissue Chemokine (SLC) ELISA Kit

MBS269092

48-Strip-Wells

290 USD

ELISA Kit

Rat Secondary Lymphoid Tissue Chemokine (SLC) ELISA Kit

Secondary Lymphoid Tissue Chemokine (SLC)

secondary lymphoid tissue chemokine; C-C motif chemokine 21; C-C motif chemokine 21; beta chemokine exodus-2; secondary lymphoid tissue chemokine; Efficient Chemoattractant for Lymphocytes; small inducible cytokine subfamily A (Cys-Cys), member 21; chemokine (C-C motif) ligand 21; 6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21

SLC

CCL21; CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21; SCYA21; UNQ784/PRO1600; SLC

CCL21_HUMAN

Rat

134

Store all reagents at 2-8 degree C.

Samples: Rat serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant SLC concentration. Detection Range: 1000 pg/ml-15.6 pg/ml. Sensitivity: 5 pg/ml.

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

4128129

CAA06653.1

O00585

14,646 Da

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); NF-kappa B Signaling Pathway (634527)

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family. Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: extracellular space; extracellular region. Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding. Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of cell adhesion mediated by integrin; positive regulation of JNK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of receptor-mediated endocytosis; positive regulation of protein kinase B signaling cascade; G-protein coupled receptor protein signaling pathway; positive regulation of pseudopodium formation; cell-cell signaling; positive regulation of actin filament polymerization; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; establishment of T cell polarity; immune response; positive regulation of cell-matrix adhesion; inflammatory response

48-Strip-Wells

290 USD

96-Strip-Wells

450