Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit | MyBioSource MBS269035 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

catalog :

MBS269035

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS269035

products type :

ELISA Kit

products full name :

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

products short name :

N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP)

other names :

natriuretic peptides A preproprotein; Natriuretic peptides A; natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A; natriuretic peptide A; CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDP; Atrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP

products gene name :

NT-ProBNP

other gene names :

NPPA; NPPA; ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF; ANP; PND; CDP; ANF; ANP

uniprot entry name :

ANF_HUMAN

reactivity :

Human

sequence length :

151

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant NT-ProBNP concentration. Assay Type: Sandwich. Detection Range: 2000 pg/ml-31.2 pg/ml. Sensitivity: 12 pg/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human NT-ProBNP monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

23510319

ncbi acc num :

NP_006163.1

ncbi gb acc num :

NM_006172.3

ncbi mol weight :

16,708 Da

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1 Signaling Pathway (695200); MicroRNAs In Cardiomyocyte Hypertrophy Pathway (198784); YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway (576276)

ncbi summary :

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

uniprot summary :

NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family. Protein type: Hormone; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p36.21. Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus. Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; receptor binding. Biological Process: cardiac muscle hypertrophy; transcription initiation from RNA polymerase II promoter; cGMP biosynthetic process; negative regulation of systemic arterial blood pressure; positive regulation of heart rate; female pregnancy; response to insulin stimulus; neuropeptide signaling pathway; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; response to hypoxia; gene expression; negative regulation of cell growth; regulation of blood vessel size. Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage