Mouse Glucoprotein 130 (gp130) ELISA Kit | MyBioSource MBS268935 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Glucoprotein 130 (gp130) ELISA Kit

catalog :

MBS268935

quantity :

48-Strip-Wells

price :

290 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS268935

products type :

ELISA Kit

products full name :

Mouse Glucoprotein 130 (gp130) ELISA Kit

products short name :

Glucoprotein 130 (gp130)

other names :

gp130, partial; Interleukin-6 receptor subunit beta; interleukin-6 receptor subunit beta; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; gp130, oncostatin M receptor; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; interleukin 6 signal transducer; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130

products gene name :

gp130

other gene names :

IL6ST; IL6ST; CD130; GP130; CDW130; IL-6RB; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130

uniprot entry name :

IL6RB_HUMAN

reactivity :

Mouse

sequence length :

storage stability :

Store all reagents at 2-8 degree C.

ncbi gi num :

1246098

ncbi acc num :

AAB35921.1

ncbi mol weight :

96,276 Da

ncbi pathways :

Adipogenesis Pathway (198832); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-6 Signaling Pathway (198864); IL27-mediated Signaling Events Pathway (137929); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-11 Signaling Pathway (698753); Interleukin-6 Signaling Pathway (205111)

ncbi summary :

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

uniprot summary :

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: extracellular space; membrane; cell soma; oncostatin-M receptor complex; dendrite; plasma membrane; extracellular region; interleukin-6 receptor complex; external side of plasma membrane. Molecular Function: interleukin-11 binding; protein homodimerization activity; interleukin-27 receptor activity; oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; interleukin-6 receptor activity; interleukin-11 receptor activity; protein binding; interleukin-6 binding; interleukin-6 receptor binding; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding. Biological Process: glycogen metabolic process; viral reproduction; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

290 USD

size2 :

96-Strip-Wells

price2 :

450

more info or order :

MyBioSource product webpage