ELISA/assay

Human Toll Like Receptor 6 (TLR-6) ELISA Kit

MBS268581

48-Strip-Wells

275 USD

ELISA Kit

Human Toll Like Receptor 6 (TLR-6) ELISA Kit

Toll Like Receptor 6 (TLR-6)

toll-like receptor 6; Toll-like receptor 6; toll-like receptor 6; toll-like receptor 6; CD_antigen: CD286

TLR-6

TLR6; TLR6; CD286

TLR6_HUMAN

Human

796

Store all reagents at 2-8 degree C.

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant TLR-6 concentration. Assay Type: Sandwich. Detection Range: 20 ng/ml-0.312 ng/ml

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Human TLR-6 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

20143971

NP_006059.2

NM_006068.4

91,880 Da

Activated TLR4 Signalling Pathway (106400); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); Phagosome Pathway (153910); Phagosome Pathway (153859); Toll Like Receptor 2 (TLR2) Cascade Pathway (106402); Toll Like Receptor 4 (TLR4) Cascade Pathway (106398)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 4p14. Cellular Component: phagocytic vesicle membrane; integral to plasma membrane; plasma membrane. Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity; diacylated lipoprotein binding. Biological Process: positive regulation of JNK activity; T-helper 1 type immune response; regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; detection of diacylated bacterial lipoprotein; positive regulation of interleukin-6 biosynthetic process; activation of NF-kappaB-inducing kinase; signal transduction; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 6 signaling pathway; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 4 signaling pathway

48-Strip-Wells

275 USD

96-Strip-Wells

420