Human lipoteichoic acids (LTA) ELISA Kit | MyBioSource MBS268197 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human lipoteichoic acids (LTA) ELISA Kit

catalog :

MBS268197

quantity :

48-Strip-Wells

price :

275 USD

more info or order :

MyBioSource product webpage

citations: 1

Reference
Vegas A, Veiseh O, Doloff J, Ma M, Tam H, Bratlie K, et al. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016;34:345-52 pubmed publisher

product information

catalog number :

MBS268197

products type :

ELISA Kit

products full name :

Human lipoteichoic acids (LTA) ELISA Kit

products short name :

lipoteichoic acids (LTA)

other names :

LTA, partial; LTA protein; lymphotoxin-alpha; LT-alpha; TNF-beta; TNF superfamily, member 1; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1; lymphotoxin alpha; LTA protein

products gene name :

LTA

other gene names :

LTA; LTA; LT; TNFB; TNFSF1

uniprot entry name :

Q6FG55_HUMAN

reactivity :

Human

sequence length :

205

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Human serum, plasma or cell culture supernatant and organizations in the natural and recombinant LTA concentration. Assay Type: Quantitative Sandwich. Sensitivity: Up to 0.06 ng/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human LTA monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

49457540

ncbi acc num :

CAG47069.1

uniprot acc num :

Q6FG55

ncbi mol weight :

22,350 Da

ncbi pathways :

Apoptosis Pathway (198797); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); IL2 Signaling Events Mediated By STAT5 Pathway (137988); IL4-mediated Signaling Events Pathway (137933); NF-kappa B Signaling Pathway (634527)

ncbi summary :

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

LTA: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS). PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Belongs to the tumor necrosis factor family. Protein type: Secreted; Secreted, signal peptide; Cytokine; Apoptosis. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: extracellular space; membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: response to drug; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of apoptosis; apoptosis; response to lipopolysaccharide; signal transduction; lymph node development; humoral immune response; defense response to Gram-positive bacterium; positive regulation of interferon-gamma production; cell-cell signaling; negative regulation of fibroblast proliferation; response to hypoxia; positive regulation of chronic inflammatory response to antigenic stimulus; response to nutrient. Disease: Psoriatic Arthritis, Susceptibility To; Myocardial Infarction, Susceptibility To; Leprosy, Susceptibility To, 4

size1 :

48-Strip-Wells

price1 :

275 USD

size2 :

96-Strip-Wells

price2 :

420

more info or order :

MyBioSource product webpage