Mouse Thromboxane A2 (TX-A2) ELISA Kit | MyBioSource MBS266908 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Thromboxane A2 (TX-A2) ELISA Kit

catalog :

MBS266908

quantity :

48-Strip-Wells

price :

260 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS266908

products type :

ELISA Kit

products full name :

Mouse Thromboxane A2 (TX-A2) ELISA Kit

products short name :

[Thromboxane A2 (TX-A2)]

other names :

[thromboxane A2 receptor isoform beta; Thromboxane A2 receptor; thromboxane A2 receptor; prostanoid TP receptor; thromboxane A2 receptor; Prostanoid TP receptor]

products gene name :

[TX-A2]

other gene names :

[TBXA2R; TBXA2R; TXA2-R; BDPLT13; TXA2-R]

uniprot entry name :

TA2R_HUMAN

reactivity :

Mouse

sequence length :

407

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Mouse serum, plasma or cell culture supernatant and organizations. Assay Type: Quantitative Sandwich. Detection Range: 1000 pg/ml-15.6 pg/ml. Sensitivity: 5 pg/ml

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Mouse TX-A2 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

260593681

ncbi acc num :

NP_963998.2

ncbi gb acc num :

NM_201636.2

ncbi mol weight :

44,205 Da

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Eicosanoid Ligand-binding Receptors Pathway (106370); G Alpha (12/13) Signalling Events Pathway (106041); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295)

ncbi summary :

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

uniprot summary :

TXA2-R: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13). BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: integral to plasma membrane; acrosome; plasma membrane. Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; thromboxane A2 receptor activity. Biological Process: response to drug; second-messenger-mediated signaling; platelet activation; response to lipopolysaccharide; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; positive regulation of vasoconstriction; positive regulation of smooth muscle contraction; blood coagulation; inflammatory response; positive regulation of blood pressure; response to nutrient; positive regulation of GTPase activity

size1 :

48-Strip-Wells

price1 :

260 USD

size2 :

96-Strip-Wells

price2 :

405

size3 :

5x96-Strip-Wells

price3 :

1615

size4 :

10x96-Strip-Wells

price4 :

2880

more info or order :

MyBioSource product webpage