catalog number :
MBS265665
products type :
ELISA Kit
products full name :
Goat Orexin Receptor (OR) ELISA Kit
products short name :
Orexin Receptor (OR)
other names :
orexin receptor type 1; Orexin receptor type 1; orexin receptor type 1; ox1-R; ox-1-R; orexin receptor 1; orexin receptor-1; hypocretin receptor 1; hypocretin receptor-1; hypocretin receptor type 1; hypocretin (orexin) receptor 1; Hypocretin receptor type 1
other gene names :
HCRTR1; HCRTR1; OX1R; Ox-1-R; Ox1-R; Ox1R
uniprot entry name :
OX1R_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_001516.2
ncbi gb acc num :
NM_001525.2
ncbi mol weight :
47,536 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway (106362); Peptide Ligand-binding Receptors Pathway (106358)
ncbi summary :
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
uniprot summary :
HCRTR1: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p33. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide receptor activity; orexin receptor activity; peptide hormone binding; peptide binding. Biological Process: synaptic transmission; neuropeptide signaling pathway; feeding behavior; regulation of circadian sleep/wake cycle, sleep; cellular response to hormone stimulus