Human Interleukin 13 (IL-13) ELISA Kit | MyBioSource MBS265513 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Interleukin 13 (IL-13) ELISA Kit

catalog :

MBS265513

quantity :

48-Strip-Wells

price :

250 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS265513

products type :

ELISA Kit

products full name :

Human Interleukin 13 (IL-13) ELISA Kit

products short name :

[Interleukin 13 (IL-13)]

other names :

[interleukin-13; Interleukin-13; interleukin-13; interleukin 13]

products gene name :

[IL-13]

other gene names :

[IL13; IL13; P600; IL-13; NC30; IL-13]

uniprot entry name :

IL13_HUMAN

reactivity :

Human

sequence length :

146

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Human Serum, Plasma Or Cell Culture Supernatant And Organizations In The Natural And Recombinant Il-1 Concentration. Assay Type: Sandwich. Detection Range: 1000 pg/ml-15.6 pg/ml. Sensitivity: 5 pg/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is human IL-1 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

26787978

ncbi acc num :

NP_002179.2

ncbi gb acc num :

NM_002188.2

ncbi mol weight :

15,816 Da

ncbi pathways :

Asthma Pathway (83120); Asthma Pathway (532); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493); Glucocorticoid Receptor Regulatory Network Pathway (138014); IL12 Signaling Mediated By STAT4 Pathway (137936); Inflammatory Bowel Disease Pathway (842771)

ncbi summary :

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

uniprot summary :

IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane. Molecular Function: protein binding; interleukin-13 receptor binding; cytokine activity. Biological Process: response to nicotine; positive regulation of smooth muscle cell proliferation; regulation of proton transport; microglial cell activation; response to lipopolysaccharide; signal transduction; positive regulation of connective tissue growth factor production; positive regulation of tyrosine phosphorylation of Stat6 protein; positive regulation of immunoglobulin production; response to ethanol; positive regulation of protein secretion; cell-cell signaling; positive regulation of B cell proliferation; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; negative regulation of NAD(P)H oxidase activity; cell motility; positive regulation of macrophage activation. Disease: Asthma, Susceptibility To; Allergic Rhinitis

size1 :

48-Strip-Wells

price1 :

250 USD

size2 :

96-Strip-Wells

price2 :

365

size3 :

5x96-Strip-Wells

price3 :

1480

size4 :

10x96-Strip-Wells

price4 :

2620

more info or order :

MyBioSource product webpage