catalog number :
MBS263960
products type :
ELISA Kit
products full name :
Chicken major histocompatibility complex (MHC) ELISA Kit
products short name :
major histocompatibility complex (MHC)
other names :
major histocompatibility complex; HLA class I histocompatibility antigen, B-7 alpha chain; major histocompatibility complex, class I, B; lymphocyte antigen; MHC class I antigen SHCHA; MHC Class I HLA heavy chain; MHC class I antigen GN00104; leukocyte antigen class I-B; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen HLA-B heavy chain; HLA class I histocompatibility antigen, B alpha chain; major histocompatibility complex, class I, B; MHC class I antigen B*7
other gene names :
HLA-B; HLA-B; AS; HLAB; SPDA1; HLAB
uniprot entry name :
1B07_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
AAC41979.1
ncbi mol weight :
40,460 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway 366163!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Antigen Processing-Cross Presentation Pathway 477122!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Cell Adhesion Molecules (CAMs) Pathway 83069
ncbi summary :
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]