ELISA/assay

Human substance P receptor (SP-R) ELISA Kit

MBS262767

48-Strip-Wells

275 USD

ELISA Kit

Human substance P receptor (SP-R) ELISA Kit

substance P receptor (SP-R)

substance P receptor; Substance-P receptor; substance-P receptor; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); tachykinin receptor 1; NK-1 receptor; NK-1R; Tachykinin receptor 1

SP-R

TACR1; TACR1; SPR; NK1R; NKIR; TAC1R; NK1R; TAC1R; SPR; NK-1R

NK1R_HUMAN

Human

407

Store all reagents at 2-8 degree C.

Samples: Human serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant SP-R concentration. Detection Range: 20 ng/ml-0.312 ng/ml. Sensitivity: 0.06 ng/ml.

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

338613

AAA60601.1

35,713 Da

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Measles Pathway (213306); Measles Pathway (213277); Neuroactive Ligand-receptor Interaction Pathway (83053)

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P substance K neuromedin-K. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2p12. Cellular Component: cell surface; integral to plasma membrane; dendrite; cytoplasm; plasma membrane. Molecular Function: protein binding; substance P receptor activity; tachykinin receptor activity. Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to morphine; positive regulation of saliva secretion; response to estradiol stimulus; behavioral response to pain; elevation of cytosolic calcium ion concentration; regulation of smooth muscle cell migration; positive regulation of lymphocyte proliferation; positive regulation of stress fiber formation; positive regulation of action potential; response to electrical stimulus; inflammatory response; angiotensin mediated drinking behavior; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of hormone secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; response to heat; smooth muscle contraction involved in micturition; response to ozone; operant conditioning; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); sperm ejaculation; response to progesterone stimulus; acute inflammatory response; positive regulation of epithelial cell proliferation; positive regulation of blood pressure

48-Strip-Wells

275 USD

96-Strip-Wells

420