Rat Toll Like Receptor 8 (TLR-8) ELISA Kit | MyBioSource MBS261698 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Toll Like Receptor 8 (TLR-8) ELISA Kit

catalog :

MBS261698

quantity :

48-Strip-Wells

price :

290 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS261698

products type :

ELISA Kit

products full name :

Rat Toll Like Receptor 8 (TLR-8) ELISA Kit

products short name :

Toll Like Receptor 8 (TLR-8)

other names :

Toll-like receptor 8; Toll-like receptor 8; toll-like receptor 8; toll-like receptor 8; CD_antigen: CD288

products gene name :

TLR-8

other gene names :

TLR8; TLR8; CD288; UNQ249/PRO286

uniprot entry name :

TLR8_HUMAN

reactivity :

Rat

sequence length :

1041

storage stability :

Store all reagents at 2-8 degree C.

other info1 :

Samples: Rat serum, plasma or Cell Culture Supernatant and organizations in the natural and recombinant TLR-8 concentration. Assay Type: Sandwich. Detection Range: 10 ng/ml-0.156ng/ml. Sensitivity: 0.05 ng/ml.

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Rat TLR-8 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

20140873

ncbi acc num :

Q9NR97.1

ncbi mol weight :

121,764 Da

ncbi pathways :

Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88 Dependent Cascade Initiated On Endosome Pathway (187081); Regulation Of Toll-like Receptor Signaling Pathway (920955); TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway (187085); TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway (187082); Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway (106396); Toll Like Receptor 9 (TLR9) Cascade Pathway (106397); Toll-Like Receptors Cascades Pathway (106388); Toll-like Receptor Signaling Pathway (83076)

ncbi summary :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

uniprot summary :

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane. Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; immunoglobulin mediated immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process

size1 :

48-Strip-Wells

price1 :

290 USD

size2 :

96-Strip-Wells

price2 :

450

more info or order :

MyBioSource product webpage