Mouse Interleukin 6 receptor (IL-6R) ELISA Kit | MyBioSource MBS2604879 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Interleukin 6 receptor (IL-6R) ELISA Kit

catalog :

MBS2604879

quantity :

48-Strip-Wells

price :

260 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS2604879

products type :

ELISA Kit

products full name :

Mouse Interleukin 6 receptor (IL-6R) ELISA Kit

products short name :

[Interleukin 6 receptor]

other names :

[interleukin-6-receptor; Interleukin-6 receptor subunit alpha; interleukin-6 receptor subunit alpha; interleukin 6 receptor; IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126]

products gene name :

[IL-6R]

other gene names :

[IL6R; IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80]

uniprot entry name :

IL6RA_HUMAN

reactivity :

Mouse

sequence length :

468

specificity :

No cross-reaction with other factors.

storage stability :

Store all reagents at 2-8 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Mouse serum, plasma or cell culture supernatant and organizations. Assay Type: Quantitative Sandwich. Detection Range: 10 ng/ml-0.156 ng/ml. Sensitivity: 0.05 ng/ml

other info2 :

Intra-assay Precision: <= 8%. Inter-assay Precision: <= 12%

products description :

Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Mouse IL-6R monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.

ncbi gi num :

32581

ncbi acc num :

CAA41231.1

uniprot acc num :

P08887

ncbi mol weight :

40,237 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HIF-1 Signaling Pathway (695200); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-6 Signaling Pathway (198864); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (1269170); Interleukin-6 Family Signaling Pathway (1339142)

ncbi summary :

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

uniprot summary :

IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: apical plasma membrane; basolateral plasma membrane; extracellular region; extracellular space; interleukin-6 receptor complex; plasma membrane. Molecular Function: ciliary neurotrophic factor receptor activity; enzyme binding; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; protein binding; protein homodimerization activity. Biological Process: activation of NF-kappaB transcription factor; acute-phase response; cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; endocrine pancreas development; hepatic immune response; monocyte chemotaxis; negative regulation of collagen biosynthetic process; negative regulation of interleukin-8 production; neutrophil mediated immunity; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; positive regulation of MAPKKK cascade; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; response to cytokine stimulus. Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus

size1 :

48-Strip-Wells

price1 :

260 USD

size2 :

96-Strip-Wells

price2 :

405

size3 :

5x96-Strip-Wells

price3 :

1615

size4 :

10x96-Strip-Wells

price4 :

2880

more info or order :

MyBioSource product webpage