catalog number :
MBS2602996
products type :
ELISA Kit
products full name :
Bovine DNA repair protein XRCC3, XRCC3 ELISA Kit
products short name :
X-ray repair complementing defective repair in Chinese hamster cells 3
other names :
DNA repair protein XRCC3; DNA repair protein XRCC3; DNA repair protein XRCC3; X-ray repair cross-complementing protein 3; X-ray repair complementing defective repair in Chinese hamster cells 3<; X-ray repair cross-complementing protein 3
other gene names :
XRCC3; XRCC3
uniprot entry name :
XRCC3_BOVIN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_001071585.1
ncbi gb acc num :
NM_001078117.1
ncbi mol weight :
36,755 Da
ncbi pathways :
Homologous Recombination Pathway 84285!!Homologous Recombination Pathway 454
uniprot summary :
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C