product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Nicotinamide mononucleotide adenylyltransferase 2, NMNAT2 ELISA Kit
catalog :
MBS2602991
quantity :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602991
products type :
ELISA Kit
products full name :
Human Nicotinamide mononucleotide adenylyltransferase 2, NMNAT2 ELISA Kit
products short name :
nicotinamide nucleotide adenylyltransferase 2
other names :
nicotinamide mononucleotide adenylyltransferase 2 isoform 1; Nicotinamide mononucleotide adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2; pyridine nucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 2; nicotinamide nucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2 (EC:2.7.7.18); NaMN adenylyltransferase 2
other gene names :
NMNAT2; NMNAT2; PNAT2; C1orf15; C1orf15; KIAA0479; NMN adenylyltransferase 2; NaMN adenylyltransferase 2
uniprot entry name :
NMNA2_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
24307989
ncbi acc num :
NP_055854.1
ncbi gb acc num :
NM_015039.3
uniprot acc num :
Q9BZQ4
ncbi mol weight :
34,439 Da
ncbi pathways :
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001!!Defective GIF Causes Intrinsic Factor Deficiency Pathway 906004!!Defective HLCS Causes Multiple Carboxylase Deficiency Pathway 906014!!Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway 906003!!Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway 906010!!Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway 906009!!Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway 906005
ncbi summary :
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity prefers NAD+, NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+.2 PublicationsManual assertion based on experiment in:Ref.7. Catalytic activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD+. Cofactor: Divalent metal cations. Magnesium confers the highest activity.3 PublicationsManual assertion based on experiment in:Ref.5. Enzyme regulation: Inhibited by P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate (Np3AD) and P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate (Np4AD).1 PublicationManual assertion based on experiment in:Ref.8
size :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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