ELISA/assay

Human A-kinase anchor protein 13, AKAP13 ELISA Kit

MBS2602987

96 Strip Wells

420 USD

ELISA Kit

Human A-kinase anchor protein 13, AKAP13 ELISA Kit

A kinase (PRKA) anchor protein 13

A-kinase anchor protein 13 isoform 4; A-kinase anchor protein 13; A-kinase anchor protein 13; LBC oncogene; A-kinase anchoring protein; lymphoid blast crisis oncogene; human thyroid-anchoring protein 31; protein kinase A-anchoring protein 13; guanine nucleotide exchange factor Lbc; non-oncogenic Rho GTPase-specific GTP exchange factor; breast cancer nuclear receptor-binding auxiliary protein; A kinase (PRKA) anchor protein 13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47

AKAP13; AKAP13; BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC; BRX; HT31; LBC; AKAP-13; LBC oncogene; PRKA13

AKP13_HUMAN

Human

Store all reagents at 2-8 degree C.

395627649

NP_001257475.1

NM_001270546.1

Q12802

307,550 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!G Protein Signaling Pathways 198849!!G Alpha (12/13) Signalling Events Pathway 106041!!GPCR Downstream Signaling Pathway 119548!!NRAGE Signals Death Through JNK Pathway 106444!!Regulation Of RhoA Activity Pathway 138070!!Rho GTPase Cycle Pathway 106503!!Signal Transduction Pathway 477114!!Signaling By GPCR Pathway 106356!!Signaling By Rho GTPases Pathway 106502

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

Function: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element-specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions.4 PublicationsManual assertion based on experiment in:Ref.2

96 Strip Wells

420 USD