product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Pig TGF-beta receptor type-1, TGFBR1 ELISA Kit
catalog :
MBS2602916
quantity :
96 Strip Wells
price :
490 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602916
products type :
ELISA Kit
products full name :
Pig TGF-beta receptor type-1, TGFBR1 ELISA Kit
products short name :
transforming growth factor, beta receptor 1
other names :
TGF-beta receptor type-1; TGF-beta receptor type-1; TGF-beta receptor type-1; TGFR-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin A receptor type II-like kinase; transforming growth factor beta receptor type I; transforming growth factor-beta receptor type I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
other gene names :
TGFBR1; TGFBR1; ALK-5; TGFR-1; TGF-beta receptor type I; TbetaR-I
uniprot entry name :
TGFR1_PIG
reactivity :
Pig
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
84490427
ncbi acc num :
NP_001033728.1
ncbi gb acc num :
NM_001038639.1
uniprot acc num :
Q5CD18
ncbi mol weight :
56,174 Da
ncbi pathways :
Adherens Junction Pathway 84482!!Adherens Junction Pathway 481!!Chagas Disease (American Trypanosomiasis) Pathway 147807!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chronic Myeloid Leukemia Pathway 84523!!Chronic Myeloid Leukemia Pathway 528!!Colorectal Cancer Pathway 84513!!Colorectal Cancer Pathway 518!!Cytokine-cytokine Receptor Interaction Pathway 84463!!Cytokine-cytokine Receptor Interaction Pathway 460
uniprot summary :
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation . Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. Cofactor: Magnesium or manganese . Enzyme regulation: Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor
size :
96 Strip Wells
price :
490 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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