catalog number :
MBS2602907
products type :
ELISA Kit
products full name :
Human 5-hydroxytryptamine receptor 6, HTR6 ELISA Kit
products short name :
5-hydroxytryptamine (serotonin) receptor 6
other names :
5-hydroxytryptamine receptor 6; 5-hydroxytryptamine receptor 6; 5-hydroxytryptamine receptor 6; serotonin receptor 6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; Serotonin receptor 6
other gene names :
HTR6; HTR6; 5-HT6; 5-HT6R; 5-HT-6; 5-HT6
uniprot entry name :
5HT6R_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_000862.1
ncbi gb acc num :
NM_000871.2
ncbi mol weight :
46,954 Da
ncbi pathways :
Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Monoamine GPCRs Pathway (198861); Neuroactive Ligand-receptor Interaction Pathway (83053)
ncbi summary :
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
uniprot summary :
5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p36-p35. Cellular Component: integral to plasma membrane; dendrite; plasma membrane; cilium. Molecular Function: protein binding; serotonin receptor activity; histamine receptor activity. Biological Process: response to drug; positive regulation of dopamine secretion; negative regulation of glutamate secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of acetylcholine secretion; learning; response to estradiol stimulus; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cerebral cortex cell migration; positive regulation of TOR signaling pathway; serotonin receptor signaling pathway; positive regulation of gamma-aminobutyric acid secretion