catalog number :
MBS2602886
products type :
ELISA Kit
products full name :
Human Dolichol kinase, DOLK ELISA Kit
products short name :
dolichol kinase
other names :
dolichol kinase; Dolichol kinase; dolichol kinase; SEC59 homolog; dolichol kinase 1; transmembrane protein 15; dolichol kinase; Transmembrane protein 15
other gene names :
DOLK; DOLK; DK; DK1; CDG1M; SEC59; TMEM15; KIAA1094; TMEM15; UNQ2422/PRO4980
uniprot entry name :
DOLK_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_055723.1
ncbi gb acc num :
NM_014908.3
ncbi mol weight :
59,268 Da
ncbi pathways :
Asparagine N-linked Glycosylation Pathway 161013!!Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway 161014!!Metabolism Of Proteins Pathway 106230!!N-Glycan Biosynthesis Pathway 82975!!N-Glycan Biosynthesis Pathway 345!!Post-translational Protein Modification Pathway 161012!!Synthesis Of Dolichyl-phosphate Pathway 161016!!Synthesis Of Substrates In N-glycan Biosythesis Pathway 161015!!Dolichol And Dolichyl Phosphate Biosynthesis Pathway 545306
ncbi summary :
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
uniprot summary :
Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors . Catalytic activity: CTP + dolichol = CDP + dolichyl phosphate.