catalog number :
MBS2602878
products type :
ELISA Kit
products full name :
Human 15-Hydroxyprostaglandin Dehydrogenase, 15-PGDH ELISA Kit
products short name :
hydroxyprostaglandin dehydrogenase 15- (NAD)
other names :
15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; prostaglandin dehydrogenase 1; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 36C, member 1; hydroxyprostaglandin dehydrogenase 15-(NAD); Prostaglandin dehydrogenase 1
other gene names :
HPGD; HPGD; PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1; PGDH1; 15-PGDH
uniprot entry name :
PGDH_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_000851.2
ncbi gb acc num :
NM_000860.5
ncbi mol weight :
28,977 Da
ncbi pathways :
Arachidonic Acid Metabolism Pathway 685553!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Prostaglandin Synthesis And Regulation Pathway 198912!!Synthesis Of Lipoxins (LX) Pathway 730338!!Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway 730333!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987
ncbi summary :
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
uniprot summary :
Function: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.3 PublicationsManual assertion based on experiment in:Ref.11. Catalytic activity: (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.