This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
ELISA/assay
product name :
Bovine Serine/threonine-protein kinase PLK4, PLK4 ELISA Kit
catalog :
MBS2602874
quantity :
96 Strip Wells
price :
490 USD
product information
catalog number :
MBS2602874
products type :
ELISA Kit
products full name :
Bovine Serine/threonine-protein kinase PLK4, PLK4 ELISA Kit
products short name :
polo-like kinase 4 (Drosophila)
other names :
serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase PLK4; serine/threonine-protein kinase PLK4; serine/threonine-protein kinase Sak; polo-like kinase 4<; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase Sak
other gene names :
PLK4; PLK4; PLK-4; SAK; PLK-4
uniprot entry name :
PLK4_BOVIN
reactivity :
Bovine
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
134085942
ncbi acc num :
NP_001076896.1
ncbi gb acc num :
NM_001083427.2
uniprot acc num :
A2VDZ4
ncbi mol weight :
100,707 Da
ncbi pathways :
Cell Cycle Pathway 581204!!Cell Cycle, Mitotic Pathway 581226!!Centrosome Maturation Pathway 581263!!G2/M Transition Pathway 581259!!Loss Of Nlp From Mitotic Centrosomes Pathway 581267!!Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway 581266!!Mitotic G2-G2/M Phases Pathway 581257!!Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway 581264
uniprot summary :
Function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2 . Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
size :
96 Strip Wells
price :
490 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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