catalog number :
MBS2602872
products type :
ELISA Kit
products full name :
Human Acetyl-CoA carboxylase 2, ACACB ELISA Kit
products short name :
acetyl-Coenzyme A carboxylase beta
other names :
acetyl-CoA carboxylase 2; Acetyl-CoA carboxylase 2; acetyl-CoA carboxylase 2; ACC-beta; acetyl-Coenzyme A carboxylase beta; acetyl-CoA carboxylase beta; ACC-betaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14)
other gene names :
ACACB; ACACB; ACC2; ACCB; HACC275; ACC2; ACCB
uniprot entry name :
ACACB_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_001084.3
ncbi gb acc num :
NM_001093.3
ncbi mol weight :
276,541 Da
ncbi pathways :
AMPK Signaling Pathway 198868!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!ChREBP Activates Metabolic Gene Expression Pathway 106104!!Fatty Acid Biosynthesis Pathway 198873!!Fatty Acid Biosynthesis Pathway 82933!!Fatty Acid Biosynthesis Pathway 294!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway 106108!!Insulin Signaling Pathway 83090
ncbi summary :
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Catalytic activity: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.1 PublicationManual assertion based on experiment in:Ref.9. Cofactor: Biotin 1 PublicationManual assertion based on experiment in:Ref.2. Enzyme regulation: Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA.2 PublicationsManual assertion based on experiment in:Ref.2