product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Rat Cytochrome P450 3A4, CYP3A4 ELISA Kit
catalog :
MBS2602859
quantity :
96 Strip Wells
price :
450 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602859
products type :
ELISA Kit
products full name :
Rat Cytochrome P450 3A4, CYP3A4 ELISA Kit
products short name :
Cytochrome P450 3A4 (CYP3A4)
other names :
cytochrome P450 3A4 isoform 2; Cytochrome P450 3A4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; 1,8-cineole 2-exo-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, family 3, subfamily A, polypeptide 4; 1,8-cineole 2-exo-monooxygenase (EC:1.14.13.157); Albendazole monooxygenase (EC:1.14.13.32); Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase (EC:1.14.13.67); Taurochenodeoxycholate 6-alpha-hydroxylase (EC:1.14.13.97)
other gene names :
CYP3A4; CYP3A4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; CYP3A3
uniprot entry name :
CP3A4_HUMAN
reactivity :
Rat
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
322302351
ncbi acc num :
NP_001189784.1
ncbi gb acc num :
NM_001202855.2
uniprot acc num :
P08684
ncbi mol weight :
57,343 Da
ncbi pathways :
Aflatoxin B1 Metabolism Pathway 198808!!Aflatoxin Activation And Detoxification Pathway 1016173!!Benzo(a)pyrene Metabolism Pathway 198911!!Bile Secretion Pathway 193146!!Bile Secretion Pathway 193095!!Biological Oxidations Pathway 105698!!Chemical Carcinogenesis Pathway 673221!!Chemical Carcinogenesis Pathway 673237!!Codeine And Morphine Metabolism Pathway 198831!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700
ncbi summary :
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
uniprot summary :
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.1 PublicationManual assertion based on experiment in:Ref.17. Catalytic activity: Quinine + NADPH + O2 = 3-hydroxyquinine + NADP+ + H2O.1 PublicationManual assertion based on experiment in:Ref.17. Cofactor: Heme group.
size :
96 Strip Wells
price :
450 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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