ELISA/assay

Mouse 5-Hydroxytryptamine receptor 2A, 5HTR 2A ELISA Kit

MBS2602855

48-Strip-Wells

290 USD

ELISA Kit

Mouse 5-Hydroxytryptamine receptor 2A, 5HTR 2A ELISA Kit

5-Hydroxytryptamine receptor 2A, 5HTR 2A

5-hydroxytryptamine receptor 2A isoform 2; 5-hydroxytryptamine receptor 2A; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; Serotonin receptor 2A

HTR2A; HTR2A; HTR2; 5-HT2A; HTR2; 5-HT-2; 5-HT-2A

5HT2A_HUMAN

Mouse

Store all reagents at 2-8 degree C.

260099679

NP_001159419.1

NM_001165947.2

P28223

43,940 Da

Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Gap Junction Pathway (83072)

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 13q14-q21. Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol. Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding. Biological Process: urinary bladder smooth muscle contraction; cell death; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; aging; regulation of behavior; response to drug; serotonin receptor, phospholipase C activating pathway; negative regulation of synaptic transmission, glutamatergic; regulation of hormone secretion; sleep; positive regulation of phosphatidylinositol biosynthetic process; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation. Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder

48-Strip-Wells

290 USD

96-Strip-Wells

450