product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Thrombopoietin receptor, MPL ELISA Kit
catalog :
MBS2602843
quantity :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602843
products type :
ELISA Kit
products full name :
Human Thrombopoietin receptor, MPL ELISA Kit
products short name :
myeloproliferative leukemia virus oncogene
other names :
thrombopoietin receptor; Thrombopoietin receptor; thrombopoietin receptor; TPO-R; proto-oncogene c-Mpl; myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; MPL proto-oncogene, thrombopoietin receptor; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD_antigen: CD110
other gene names :
MPL; MPL; MPLV; TPOR; C-MPL; CD110; THCYT2; TPOR; TPO-R
uniprot entry name :
TPOR_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
4885491
ncbi acc num :
NP_005364.1
ncbi gb acc num :
NM_005373.2
uniprot acc num :
P40238
ncbi mol weight :
71,245 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Hemostasis Pathway 106028!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!Platelet Aggregation (Plug Formation) Pathway 106053!!Platelet Activation, Signaling And Aggregation Pathway 106034
ncbi summary :
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
size :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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