product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human alpha-ketoglutarate dehy-drogenase, alpha-KGDHC ELISA Kit
catalog :
MBS2602828
quantity :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602828
products type :
ELISA Kit
products full name :
Human alpha-ketoglutarate dehy-drogenase, alpha-KGDHC ELISA Kit
products short name :
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
other names :
2-oxoglutarate dehydrogenase, mitochondrial isoform 2; 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase, mitochondrial; OGDC-E1; oxoglutarate decarboxylase; 2-oxoglutarate dehydrogenase complex component E1; oxoglutarate dehydrogenase (succinyl-transferring); oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
other gene names :
OGDH; OGDH; E1k; OGDC; AKGDH; OGDC-E1
uniprot entry name :
ODO1_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
51873038
ncbi acc num :
NP_001003941.1
ncbi gb acc num :
NM_001003941.2
uniprot acc num :
Q02218
ncbi mol weight :
115,935 Da
ncbi pathways :
2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway 142336!!2-oxoglutarate Decarboxylation To Succinyl-CoA Pathway 139119!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Citrate Cycle (TCA Cycle) Pathway 82927!!Citrate Cycle (TCA Cycle) Pathway 288!!Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway 855811!!Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway 468202!!Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate = Oxaloacetate Pathway 413348!!Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate = Oxaloacetate Pathway 468204
ncbi summary :
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
uniprot summary :
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Catalytic activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. Cofactor: Thiamine pyrophosphate. Enzyme regulation: Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity.1 PublicationManual assertion based on experiment in:Ref.10
size :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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