product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit
catalog :
MBS2602819
quantity :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602819
products type :
ELISA Kit
products full name :
Human Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit
products short name :
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
other names :
histone-lysine N-methyltransferase 2E; Histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; myeloid/lymphoid or mixed-lineage leukemia protein 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); lysine (K)-specific methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5
other gene names :
KMT2E; KMT2E; MLL5; NKp44L; HDCMC04P; MLL5; Lysine N-methyltransferase 2E
uniprot entry name :
KMT2E_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
91199543
ncbi acc num :
NP_061152.3
ncbi gb acc num :
NM_018682.3
uniprot acc num :
Q8IZD2
ncbi mol weight :
131,737 Da
ncbi pathways :
Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320
ncbi summary :
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.4 PublicationsManual assertion based on experiment in:Ref.2. Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 PublicationManual assertion based on experiment in:Ref.10
size :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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