catalog number :
MBS2602815
products type :
ELISA Kit
products full name :
Pig Kit ligand, KITLG ELISA Kit
products short name :
KIT ligand
other names :
kit ligand; Kit ligand; kit ligand; MGF; SCF; c-kit ligand; stem cell factor; mast cell growth factor; Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligandCleaved into the following chain:Soluble KIT ligand; sKITLG
other gene names :
KITLG; KITLG; KITL; MGF; MGF; SCF; sKITLG
uniprot entry name :
SCF_PIG
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_999434.2
ncbi gb acc num :
NM_214269.2
ncbi mol weight :
31,119 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 84463!!Cytokine-cytokine Receptor Interaction Pathway 460!!Hematopoietic Cell Lineage Pathway 84490!!Hematopoietic Cell Lineage Pathway 489!!Melanogenesis Pathway 84503!!Melanogenesis Pathway 504!!PI3K-Akt Signaling Pathway 692249!!PI3K-Akt Signaling Pathway 692979!!Pathways In Cancer 84512!!Rap1 Signaling Pathway 869519
uniprot summary :
Function: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins