product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Histone-lysine N-methyltransferase SETDB1, SETDB1 ELISA Kit
catalog :
MBS2602809
quantity :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS2602809
products type :
ELISA Kit
products full name :
Human Histone-lysine N-methyltransferase SETDB1, SETDB1 ELISA Kit
products short name :
SET domain, bifurcated 1
other names :
histone-lysine N-methyltransferase SETDB1 isoform 1; Histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase SETDB1; H3-K9-HMTase 4; tudor domain containing 21; lysine N-methyltransferase 1E; histone H3-K9 methyltransferase 4; ERG-associated protein with SET domain; ERG-associated protein with a SET domain, ESET; histone-lysine N-methyltransferase, H3lysine-9 specific 4; SET domain, bifurcated 1; ERG-associated protein with SET domain; ESET; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1
other gene names :
SETDB1; SETDB1; ESET; KG1T; KMT1E; TDRD21; H3-K9-HMTase4; KIAA0067; KMT1E; ESET; H3-K9-HMTase 4
uniprot entry name :
SETB1_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
ncbi gi num :
224177467
ncbi acc num :
NP_001138887.1
ncbi gb acc num :
NM_001145415.1
uniprot acc num :
Q15047
ncbi mol weight :
143,157 Da
ncbi pathways :
Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320!!Noncanonical Wnt Signaling Pathway 169354
ncbi summary :
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
uniprot summary :
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.4 PublicationsManual assertion based on experiment in:Ref.6. Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
size :
96 Strip Wells
price :
420 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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