catalog number :
MBS2602806
products type :
ELISA Kit
products full name :
Human Dynactin subunit 3, DCTN3 ELISA Kit
products short name :
dynactin 3 (p22)
other names :
dynactin subunit 3 isoform 3; Dynactin subunit 3; dynactin subunit 3; dynactin light chain; dynactin complex subunit 22 kDa subunit; dynactin 3 (p22); Dynactin complex subunit 22 kDa subunit; p22
other gene names :
DCTN3; DCTN3; DCTN22; DCTN-22; DCTN22; p22
uniprot entry name :
DCTN3_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_001268354.1
ncbi gb acc num :
NM_001281425.1
ncbi mol weight :
21,119 Da
ncbi pathways :
Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Centrosome Maturation Pathway 105807!!G2/M Transition Pathway 105801!!Loss Of Nlp From Mitotic Centrosomes Pathway 105811!!Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway 105810!!Mitotic G2-G2/M Phases Pathway 160942!!Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway 105808
ncbi summary :
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
uniprot summary :
Function: Together with dynein may be involved in spindle assembly and cytokinesis.1 PublicationManual assertion based on experiment in:Ref.1